This page contains information and resources related to Chronic Fatigue Syndrome (CFS) and how CFS is often found as a comorbid condition to Ehlers-Danlos Syndromes.

“A proportion of those with CFS likely have EDS that has not been identified.” (Source – PubMed

Chronic fatigue syndrome(CFS)/systemic exertion intolerance disease (SEID)/myalgic encephalomyelitis (ME) is defined as,

Chronic fatigue syndrome (CFS) is a complex medical condition, characterized by long-term fatigue and other symptoms.[1][2] These symptoms are to such a degree that they limit a person’s ability to carry out ordinary daily activities.[2] CFS may also be referred to as systemic exertion intolerance disease (SEID), myalgic encephalomyelitis (ME), post-viral fatigue syndrome (PVFS), chronic fatigue immune dysfunction syndrome (CFIDS), or several other terms.[3] Quality of life of persons with CFS can be extremely compromised.[4]

Biological, genetic, infectious, and psychological mechanisms have been proposed, but the cause is not understood.[5][6] Diagnosis is based on a person’s signs and symptoms.[7] The fatigue is not due to ongoing exertion, not relieved much by rest, and is not caused by other medical conditions.[8] Evidence suggests that counseling, a gradual increase in exercise, and the medication rintatolimod is useful in some people.[9] In 2012 the FDA considered that evidence for the safety or benefit of rintatolimod to be insufficient to approve its use in the United States.[10]

Estimates of the number of people with the condition vary from 7 to 3,000 per 100,000 adults.[5][11] About one million Americans and a quarter of a million people in the UK have CFS.[12][13] Fatigue is a common symptom in many illnesses, but the fatigue experienced by persons with CFS is comparatively rare.[11] CFS occurs more often in women than men,[14] and is less common among children and adolescents.[15]

There is agreement that CFS has a negative effect on health, happiness and productivity. However, various physicians’ groups, researchers and patient advocates promote differing terminology, diagnostic criteria, proposed causes and treatments, resulting in controversy about many aspects of the disorder. The name “chronic fatigue syndrome” is controversial; many patients and advocacy groups, as well as some experts, believe the name trivializes the medical condition and they promote a name change.[16]” –

Chronic Fatigue Syndrome and EDS/HSD information and resources: 

Page last updated: July 11th, 2017